[LINK] "Bone marrow transplant eliminates HIV traces from two patients' DNA: Call it a cure?"

[rfmcdonald]

Via Towleroad, I found this CBS article by Ryan Jaslow reporting on a noteworthy step in the development of a cure for HIV.

Two men who've had HIV for years may now be free of the disease following bone marrow transplants, researchers at Brigham and Women's Hospital in Boston announced Thursday.

[. . .]

Both patients were being treated for cases of cancer. One of the patients underwent a bone marrow transplant two years ago at the Dana-Farber/Brigham and Women's Cancer Center in Boston, the other had the procedure done four years ago at the same hospital. NBCNews.com reports that one of the patients is in his 50s and has been infected since the early 1980s towards the beginning of the AIDS epidemic and the other man, in his 20s, was infected at birth.

Both stayed on their antiretroviral medication regimens, the standard treatment of HIV, following the transplants.

The researchers discovered that overtime as the patients' cells were replaced by cells from the donor, evidence of HIV in the patients' blood tests disappeared. The researchers also said both patients have no signs of HIV in their DNA or RNA and levels of their disease-fighting antibodies have also decreased. The researchers think the medications helped allow these cells to be replaced.

"This gives us some important information," one of the researchers Dr. Daniel Kuritzkes, an infectious disease specialist at the hospital and Harvard Medical school said in a press release. "It suggests that under the cover of antiretroviral therapy, the cells that repopulated the patient's immune system appear to be protected from becoming re-infected with HIV."

[. . .]

The researchers' announcement comes days after Timothy Ray Brown, the man known as the "Berlin Patient," held a press conference in Washington, D.C., to say he's still cured of AIDS five years after undergoing a bone marrow blood transplant.

However, the researchers noted differences in their two patients' treatment compared to that of Brown.

In Brown's case, his donor was specifically chosen because he possessed a genetic mutation that's found in one person of Caucasian people that makes them resistant to developing HIV. But the donors for the two Boston patient were selected at random. Additionally, Brown had stopped taking his antiretroviral medications following his transplant, while the Boston patients have stayed on the drugs.